Comparison of Myocardial Injury After Noncardiac Surgery (MINS) Incidence in Supine vs. Prone Positioning During Percutaneous Nephrolithotomy (PNL)

About this trial

Last updated a year ago

Study ID

3211789

Status

Not yet recruiting

Type

Interventional

Phase

N/A

Placebo

Accepting

40+ Years

All Sexes

Trial Timing

Started a year ago

What is this trial about?

This prospective cohort study aims to compare the incidence of Myocardial Injury after Noncardiac Surgery (MINS) in patients undergoing percutaneous nephrolithotomy (PNL) for kidney stones in supine versus prone positioning. MINS is defined as an elevated postoperative troponin level (≥0.03 ng/mL) within 48 hours after surgery. Approximately 400 patients will be enrolled, with 200 patients in each positioning group (supine and prone). The primary outcome is the incidence of MINS, assessed through troponin measurements and electrocardiogram (ECG) findings. Secondary outcomes include intraoperative complications, duration of surgery, and postoperative recovery metrics. The study seeks to determine whether surgical positioning impacts MINS risk, potentially guiding safer surgical practices.

What are the participation requirements?

Inclusion Criteria

* Age ≥40 years.

* Patients undergoing percutaneous nephrolithotomy (PNL) for kidney stones.

* Willing and able to provide informed consent.

Exclusion Criteria

* Known coronary artery disease, heart failure, or other significant cardiovascular conditions.

* Elevated preoperative troponin levels (≥0.03 ng/mL).

* Major intraoperative complications (e.g., severe bleeding requiring transfusion).

* Inability to comply with study procedures.