Evaluation of the Anti-cavity Efficacy of Three Dentifrices Using an Intra-oral Enamel Demineralization - Remineralization In-Situ Model

* Males and females, between 18-70 years of age (inclusive);

* Informed Consent Form signed and availability for the duration of the study;

* Good general health (absence of any condition that, in the opinion of the Principal Investigator, might constitute a risk to the subject while participating in the study. Examples include heart problems, valve/hip replacements, etc);

* Willingness to provide information related to their medical history;

* Minimum of 20 uncrowned permanent natural teeth (excluding third molars); Normal salivary flow;

* Willingness to wear an intra-oral appliance all day as instructed except when eating and drinking.

* Oral pathology, chronic disease, or a history of allergy to testing products;

* Subject using anticonvulsants, antihistamines, antidepressants, sedatives, tranquilizers, anti-inflammatory medication or daily analgesics within one month prior to the start of the study or scheduled to start such intake during the course of the study;

* Subject participating in any other clinical study;

* Subject pregnant or breastfeeding;

* Subject allergic to oral care products, personal care consumer products, or their ingredients;

* Extended use of antibiotics or therapeutic mouthwash any time during the three months prior to entry into the study;

* A medical history reporting that the subject has a current systemic or autoimmune disease, such as diabetes, lupus, etc.;

* Ongoing use of medications known to affect the gingival tissues (i.e. calcium channel blockers, phenytoin, cyclosporine);

* Advanced periodontal disease (purulent exudate, tooth mobility, and/or extensive loss of periodontal attachment or alveolar bone). Pocket depth equal or greater than 4 mm

* Five or more decayed, untreated dental sites (cavities);

* Current smokers and subjects with a history of alcohol or drug abuse;

* Dental work prevents wearing of the appliance or a reported need to wear a night guard.