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Adipose Tissue, Brown
+10

Cold Induced Activation of Brown Adipose Tissue in Humans

Sponsored by Susanna Søberg

About this trial

Last updated 8 years ago

Study ID

H-16038581-COLDBAT

Status

Completed

Type

Interventional

Phase

N/A

Placebo

No

Accepting

18-75 Years
18 to 30 Years
Male
Male

Trial Timing

Ended 8 years ago

What is this trial about?

This study investigates cold-induced brown fat activation assessed using PET/MR scans. Subjects will participate in an acute cooling intervention day and a thermoneutral intervention day with PET/MR scans on both days. A secondary purpose is to make a validation of an infrared thermography camera by comparison of skin temperatures and SUV of the supraclavicular brown adipose tissue.

What are the participation requirements?

Yes

Inclusion Criteria

- Age 18-30 years.

- Men

- Caucasian white

- Body Mass Index 19-25 kg/m2.

- Moderate physical activity level (not more than 8-10 hours of training pr. Week)

- Ability to give informed consent.

- Ability to follow verbal and written instructions in Danish.

- Body fat percent under 21% measured at the pre-examination day.

No

Exclusion Criteria

- Chronic diseases: Hormonal: Metabolic Diseases mb. Graves, hypothyroidism, myxedema and goiter. Diabetes Melitus, Coronary heart disease (history of myocardial infarction, unstable angina pectoris, or congestive heart failure), cancer treated within last 3 years.

- Tobacco, marijuana or intravenous drug use within 1 year of screening.

- Dieting, recent weight loss (>3 kg within 3 month) or a history of an eating disorder.

- Dietary supplements.

- History of depression, psychosis, or other psychiatric illness requiring hospitalization.

- Alcohol consumption >14 units/week.

- History of alcohol abuse within the past 3 years.

- Known liver disease or elevated liver biomarkers more than 2 times upper normal levels in the preliminary investigation.

- Known kidney disease or elevated kidney biomarkers, eCRF <60 ml/min, in the preliminary investigation.

- Use of daily medications, except for seasonal use of antihistamines.

- Diagnosed sleep disturbances.

- Pacemaker or other electronics implanted in the body.

- Magnetic impressionable metal implants or foreign objects in the body inconsistent with completion of MR.

- Claustrophobia

- Communication problems, including understanding the experimental protocol

- History of contrast allergy.

- Winter swimmers.