Rituxan + BEAM and Auto Stem Cell Transplant for High Risk Lymphoma or Hodgkin's Disease
Sponsored by Baylor College of Medicine
About this trial
Last updated 7 years ago
Study ID
Status
Type
Phase
Placebo
Accepting
Trial Timing
Ended 9 years ago
What is this trial about?
What are the participation requirements?
Inclusion Criteria
* Patients with biopsy-proven, relapsed, or refractory CD20+ lymphoma, or HD.
* At least 2e6 CD34+/kg autologous PBSC stored. If patients are non-mobilizers, then at least 2e8 TNC/kg autologous marrow should be stored.
* Patient is not pregnant.
* Zubrod performance status less than or equal to 2.
* Life expectancy is not severely limited by concomitant illness.
* Left ventricular ejection fraction greater than or equal to 50%.
* No uncontrolled arrhythmias or symptomatic cardiac disease.
* FEV1, FVC and DLCO greater than or equal to 50%.
* No symptomatic pulmonary disease.
* Serum creatinine less than or equal to 1.5 mg/dL.
* Serum bilirubin less than or equal to 2X upper limit of normal, SGPT less than or equal to 3X upper limit of normal.
* No evidence of chronic active hepatitis or cirrhosis.
* No effusion or ascites greater than or equal to 1L prior to drainage.
* HIV negative.
* Patient or guardian able to sign informed consent.
* Patients of any age may be enrolled on this protocol.
Exclusion Criteria
* Anyone not meeting the above criteria.
